Polynucleotides

Polynucleotides is an innovative biotechnology in aesthetic medicine and anti-aging treatments. This scientifically proven method of skin biostimulation contains polynucleotides that stimulate the skin to rebuild in a three-way mechanism. This treatment contains highly purified Polynucleotide matrix able to activate processes of bio-regeneration in the skin both at a deep level and in the dermis. 

Polynucleotides

What Are Polynucletides?

Polynucletides is a biostimulation treatment injectable, designed to stimulate new collagen production in the dermis of the skin, to rejuvenate areas of skin laxity which can lift and tighten skin.

Designed to:

Polynucleotides offer benefits surpassing traditional skin boosters, unlocking your skin’s natural regenerative potential. While skin boosters provide immediate results such as plumping and hydration, Polynucleotides go a step further by activating fibroblast cells within the skin.

Highly Rated Treatment

This treatment is one of the most popular at Mariella Balazs Clinic, with over 100 of our clients rating it highly with it being safe and effective.

Minimal Downtime

We recommend a 24-48 hour downtime, depending on the injection method used. In some cases, downtime is minimal and may last only a few hours. Mariella will go over all the details during your consultation.

Effective Results

Results are visible 4 weeks after the first session, with optimum results visible 2 months after the second treatment. Most clients notice a huge difference within the texture tone and elasticity of the skin in the first week.

Everything you need to know

How is it administered?

Polynucleotides are administered through micro-injections that are minimally invasive. Our practitioners have been trained by the best to perform this treatment, ensuring comfort and efficacy.

How long does the treatment take?

Approximately 30 minutes

Can you treat different skin concerns?

Polynucleotides excel in addressing a wide range of concerns, including fine lines, wrinkles, scars, rosacea, inflammation and overall skin quality. They offer a versatile solution suitable for various skin types and concerns.

Is the Polynucleotide treatment painful?

Although everyone’s pain threshold varies, pain is quite minimal, thanks to topical numbing cream and fine needles. You may experience mild discomfort during the process.

How long do the results of Polynucleotide treatments last?

Results vary from 6 to 12+ months, but it does depend on the age and the skin concerns being treated.

Can Polynucleotides be combined with other aesthetic procedures?

Yes, Polynucleotides complement nearly all aesthetic treatments, offering a synergistic approach for comprehensive results. Combining treatments enhances overall facial rejuvenation.

How many sessions will I need?

The number of polynucleotide treatment sessions typically depends on your individual skin concerns and goals. However, for optimal results, most patients benefit from a course of 2 to 4 sessions spaced about 2 to 4 weeks apart. After the initial treatment course, maintenance sessions every few months may be recommended to sustain the results. Mariella would tailor the treatment plan to your specific needs during your consultation.

Pricing Per Session

Full Face £220 

Eyes £175 

Hands £349 

Scars £175

Two Session Bundle & Save

Full Face £400 (Save £40)

Eyes £330 (Save £30)

Hands £549 (Save £50)

Scars £330 (Save £30)

Frequently Asked Questions

What are Polynucleotides?

Polynucleotides are anti-ageing, anti-wrinkle nucleotide complexes that have been shown to help skin look and feel younger. Nucleotides are the building blocks of DNA and RNA, and they are found in all living cells. Polynucleotides are a special class of nucleotides that contain multiple nucleotides bonded together. They are found naturally in some foods, but they can also be synthesised in the laboratory. Polynucleotides have been shown to boost collagen production, increase skin elasticity, and reduce the appearance of fine lines and wrinkles. They are also a powerful antioxidant that can protect the skin from damage caused by free radicals. Polynucleotides are an exciting new anti-ageing ingredient that hold promise for helping skin look and feel its best.

How does it work?

Nucleofill Eyes is a unique injectable treatment that uses natural, high viscosity, high molecular weight polynucleotides to improve the appearance of the skin around the eyes. Nucleofill Eyes works in three ways: first, it strengthens and lifts the skin; second, it hydrates the skin; and third, it eliminates free radicals and protects the skin from further damage. Nucleofill Eyes is an excellent choice for those looking for a safe and effective way to improve the appearance of their skin.

Is it safe?

Nucleofill is safe, and side effects are typically mild and temporary. The most common side effects include bruising, swelling, and redness at the injection site. Nucleofill is best used by men and women over 25 who are looking for anti-ageing treatments.

 

If you are considering Nucleofill Eyes to help reduce the appearance of wrinkles, it is important to consult with a qualified aesthetician or plastic surgeon who can assess your individual needs and recommend the best treatment plan for you. With the right number of Nucleofill Eyes’ sessions, you can achieve smooth, youthful-looking skin that will help you feel confident and beautiful.

How long does the effects last?

Nucleofill Eyes is a minimally invasive procedure that can be used to refresh the appearance of the eyes quickly and effectively. Patients can expect to see a noticeable difference in the appearance of their eyes within a month or two. However, the lifting effect of Nucleofill Eyes can last for up to 18 months. After this time, patients may need to repeat the treatment to maintain their results.

When will I see results?

Nucleofill Eyes is a new type of cosmetic treatment that is said to provide excellent results in just a few sessions. But when will you see the desired results?

 

The timing of results depends on several factors, including the severity of your wrinkles, the area being treated, and your skin type. In general, most people can expect to see visible results between 30-60 days.

What kind of results can I expect?

Nucleofill Eyes works to deliver three types of effects in the Cutaneous Membrane (epidermis, dermis, and subcutaneous tissue):

 

  • Effect in the dermo-epidermal layer: This effect is responsible for the improvement in the appearance of wrinkles and fine lines.

 

  • Effect at the vascular level: This effect helps improve blood circulation, which in turn helps improve skin complexion and reduce puffiness and dark circles under the eyes.

 

  • Effect at the level of deep tissues: This effect helps to improve the overall health of the skin, including its texture, elasticity, and firmness.

 

Nucleofill Eyes is a product specifically designed to improve the appearance of puffiness and bags under the eyes, periocular wrinkles, and regeneration of skin in the periocular area. Additionally, it is also meant to improve superficial wrinkles without the use of fillers and can be used as a pre- and post-surgical treatment.

How many sessions do I need?

Nucleofill treatments are provided in a series of three to four treatments, with an interval of two-four weeks between each treatment. A minimum of two sessions is recommended to see results.

 

Nucleofill treatments have a quick turnaround time–the treatment itself only takes 30 minutes, and there is no downtime. You can immediately return to work or your normal activities after the treatment.

 

Nucleofill is a minimally invasive procedure that leverages the bio-stimulating effects of polynucleotides to improve the appearance of under-eye hollows, fine lines, and wrinkles. The result is a more youthful and rested appearance.

Is it painful?

Nucleofill treatment is not painful. Topical anaesthetic cream is applied to numb the treatment area, reducing any discomfort from the injection.

 

Some patients might experience some mild discomfort/unease depending on how they tolerate fine injections. The injections cause a quick sting, and possible swelling and mild soreness near the injection sites for one to three days.

 

In general, patients report that the overall treatment experience is quite tolerable with minimal discomfort. Treatment sessions are typically quick and easy and recovery times are also short, with most patients feeling back to their normal selves promptly after treatment.

How does it differ from Fillers?

There are many different types of fillers available today, each with their own unique benefits. However, unlike regular fillers, Nucleofill uses polynucleotides to stimulate the production of collagen and other growth factors in your skin. This helps to restore the volume and firmness of your skin, leaving it looking rejuvenated and youthful.

 

Aside from its anti-ageing effects, Nucleofill is also very effective at treating other skin conditions, such as acne scars or surgical scars. The treatment uses a combination of polynucleotide injections with microneedling to stimulate the production of new skin cells, which helps to heal and repair the damaged tissue underneath.

Is there anyone who shouldn't have it?

The treatment is not recommended for pregnant or breastfeeding women, as it is not yet known whether it is safe for them. In addition, treatment should not be performed on anyone with an active herpes infection, as this could lead to the spread of the virus. Finally, the procedure is also contraindicated for those with neoplastic diseases, as the procedure could potentially worsen the condition.

What is the treatment like?

Nucleofill is a popular choice for those seeking to achieve a more youthful appearance. The treatment involves the injection of Nucleofill into specific areas of the face, known as Bio Aesthetic Points (BAPs). Nucleofill is made from salmon DNA-based polynucleotides that prompt fibroblasts and collagen to rebuild. This makes Nucleofill an ideal choice for those who are seeking a natural way to achieve younger-looking skin. The Nucleofill treatment regime typically involves a series of treatments, spaced two-four weeks apart. The number of treatments required will depend on the individual’s skin condition and goals. However, most people will see noticeable results after just three or four treatments. Nucleofill Eyes can be used on its own or combined with other treatments for best results.

Client Reviews

Don’t Just Take My Word For It

5/5
Absolutely fantastic appointment today. Very knowledgeable and put me at ease

- Becky S.

5/5
Mariella made me feel at ease straight away. Lovely, polite and professional.

- Ashlean B.

5/5
Always fabulous results and Mariella is the best. I wouldn’t go anywhere else.

- Larissa C.

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